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Article

Defects of intergenomic communication: where do we stand?

Brain pathology (Zurich, Switzerland) - 1 Jul 2000

Hirano M, Vu T H

Abstract excerpt

An expanding number of autosomal diseases has been associated with mitochondrial DNA (mtDNA) depletion and multiple deletions. These disorders have been classified as defects of intergenomic communication because mutations of the nuclear DNA are thought to disrupt the normal cross-talk that regulates the integrity and quantity of mtDNA. In 1989, autosomal dominant progressive external ophthalmoplegia with...

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Identifiers

PMID: 10885664
DOI: 10.1111/j.1750-3639.2000.tb00277.x
PMCID: PMC8098572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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