Disorders of nuclear-mitochondrial intergenomic signaling.

doi:10.1016/j.gene.2005.03.025

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Article

Disorders of nuclear-mitochondrial intergenomic signaling.

Gene - 18 Jul 2005

Spinazzola Antonella, Zeviani Massimo

Abstract excerpt

Depletion and multiple deletions of mitochondrial DNA (mtDNA) have been associated with a number of autosomal disorders classified as defects of nuclear-mitochondrial intergenomic signaling. The mendelian forms of progressive external ophthalmoplegia (PEO) are clinically and genetically heterogeneous disorders characterized by the accumulation of multiple deletions of mtDNA in postmitotic patient's tissues. Most...

Topics

Cell Nucleus
DNA, Mitochondrial
Humans
Mitochondrial Diseases
Mitochondrial Proteins
Mutation
Nuclear Proteins
Phosphotransferases (Alcohol Group Acceptor)
Signal Transduction
Thymidine Kinase
Thymidine Phosphorylase

Source

Open in PubMed

Identifiers

PMID: 15921863
DOI: 10.1016/j.gene.2005.03.025

Genes

DGUOK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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