Article
Methylenetetrahydrofolate reductase polymorphism in Kawasaki disease.
Pediatrics international : official journal of the Japan Pediatric Society - 1 Jun 2000
Tsukahara H, Hiraoka M, Saito M, Nishida K, Kobata R, Tsuchida S, Toyooka M, Kimura H, Gejyo F, Mayumi M
Abstract excerpt
BACKGROUND: A genetic aberration in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene (677 C to T substitution) has been shown to result in reduced enzyme activity. The hypothesis tested in the present study was that a higher proportion of Kawasaki disease (KD) patients with coronary artery lesions (CAL) would have the T677 allele compared with patients without CAL and healthy subjects. METHODS: Genotypes...
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