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Article

Evaluation of enzymatic mutation detectiontrade mark in hereditary nonpolyposis colorectal cancer.

Human mutation - 1 Jan 2000

Otway R, Tetlow N, Hornby J, Kohonen-Corish M

Abstract excerpt

In hereditary nonpolyposis colorectal cancer (HNPCC), the majority of reported mutations are dispersed throughout the 35 exons of the two principal susceptibility genes, MLH1 and MSH2, and because of this complexity, rapid mutation screening methods are required. The aim of this study was to evaluate the sensitivity of the Enzymatic Mutation Detection (EMD) assay in HNPCC using genomic DNA samples with known gene...

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Source

Identifiers

PMID: 10874307
DOI: 10.1002/1098-1004(200007)16:1<61::AID-HUMU11>3.0.CO;2-H

Genes

EMD
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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