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Article

Influence of JC virus coding region genotype on risk of multiple sclerosis and progressive multifocal leukoencephalopathy.

Journal of neurovirology - 1 May 2000

Agostini H T, Ryschkewitsch C F, Baumhefner R W, Tourtellotte W W, Singer E J, Komoly S, Stoner G L

Abstract excerpt

Two features of the biology of JC virus make it a particularly suitable candidate for an agent in MS-like disease: its neurotropic capability targeting glial cells as evidenced in progressive multifocal leukoencephalopathy lesions, and its capacity for latency and persistence as illustrated by its behaviour in the kidney. JC virus is chronically or intermittently excreted in the urine by some 40% of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10871796

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Influence of JC virus coding region genotype on risk of multiple sclerosis and progressive multifocal leukoencephalopathy.PMID 10871796Read ↗

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JC virus type 2B is found more frequently in brain tissue of progressive multifocal leukoencephalopathy patients than in urine from controls.Semantic proximity Read ↗

Genotype profile of human polyomavirus JC excreted in urine of immunocompetent individuals.Semantic proximity Read ↗

JC virus in the Irish population: significant increase of genotype 2 in immunocompromised individuals.Semantic proximity Read ↗

JC virus quasispecies analysis reveals a complex viral population underlying progressive multifocal leukoencephalopathy and supports viral dissemination via the hematogenous route.Semantic proximity Read ↗

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Quasispecies Analysis of JC Virus DNA Present in Urine of Healthy SubjectsSemantic proximity Read ↗

Molecular analysis of JC virus genotypes circulating among the Italian healthy population.Semantic proximity Read ↗

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