Article
Genetic analysis of essential hypertension in Japanese populations.
Annals of the New York Academy of Sciences - 1 May 2000
Ogihara T, Katsuya T, Higaki J
Abstract excerpt
The reverse genetic approach, which examines genetic factors underlying the root of pathogenesis first, is a powerful tool to clarify the genetic cause of essential hypertension. Using the rat cross model, studies of the genetically hypertensive inbred rat model indicated several candidate loci on the rat chromosome responsible for blood pressure, but failed to identify the exact causal gene. Moreover, it was not...
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