Article
Effect of somatic hypermutation on potential N-glycosylation sites in human immunoglobulin heavy chain variable regions.
Molecular immunology - 1 Jan 2000
Dunn-Walters D, Boursier L, Spencer J
Abstract excerpt
Immunoglobulins are known to be variably glycosylated. Although most carbohydrate is likely to be associated with the constant region, the variable region may also be glycosylated. Variable region glycosylation is known to be associated with antigen binding; in one model, the presence of carbohyd...
Topics
- Base Sequence
- Glycosylation
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Intestines
- Molecular Sequence Data
- Mutation
- Plasma Cells
- Protein Processing, Post-Translational