Article
Identification of three essential regulatory gene loci governing expression of Staphylococcus epidermidis polysaccharide intercellular adhesin and biofilm formation.
Infection and immunity - 1 Jul 2000
Mack D, Rohde H, Dobinsky S, Riedewald J, Nedelmann M, Knobloch J K, Elsner H A, Feucht H H
Abstract excerpt
The formation of adherent multilayered biofilms embedded into a glycocalyx represents an essential factor in the pathogenesis of Staphylococcus epidermidis biomaterial-related infections. Using biofilm-producing S. epidermidis 1457 and transposon Tn917 carried on plasmid pTV1ts, we isolated nine isogenic biofilm-negative transposon mutants. Transduction by S. epidermidis phage 71 was used to prove the genetic...
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