Enhanced cytolytic activity of intestinal intraepithelial lymphocytes in patients with Crohn's disease.

doi:10.1007/s004230050268

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Article

Enhanced cytolytic activity of intestinal intraepithelial lymphocytes in patients with Crohn's disease.

Langenbeck's archives of surgery - 1 Apr 2000

Nüssler N C, Stange B, Hoffman R A, Schraut W H, Bauer A J, Neuhaus P

Abstract excerpt

BACKGROUND AND AIMS: Dysfunction of the immune system with inappropriate responses of lymphocytes to various antigens has been implicated in the development of Crohn's disease. Therefore, the functional and phenotypic characteristics of intestinal intraepithelial lymphocytes (IEL) in comparison to peripheral blood lymphocytes (PBL) were analyzed in patients with and without Crohn's disease. PATIENTS AND METHODS:...

Topics

Case-Control Studies
Crohn Disease
Cytotoxicity, Immunologic
Flow Cytometry
Humans
Intestinal Mucosa
Killer Cells, Natural
Phenotype
T-Lymphocytes, Cytotoxic
Tumor Cells, Cultured

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PMID: 10857494
DOI: 10.1007/s004230050268

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