Article
Disrupted transforming growth factor-beta signaling and deregulated growth in human biliary tract cancer cells.
International journal of cancer - 15 Jun 2000
Yazumi S, Ko K, Watanabe N, Shinohara H, Yoshikawa K, Chiba T, Takahashi R
Abstract excerpt
Biliary tract carcinoma is a common neoplasm in Japan, and its treatment is difficult because it tends to promote fibrosis and easily invades surrounding tissues. To better characterize the biological features of this carcinoma, we investigated abnormalities in the transforming growth factor-beta (TGF-beta) signaling pathway in five human biliary tract cancer cell lines: RBE, KMBC, SK-ChA-1, Mz-ChA-1, and...
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