Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long survival and therapeutic responses in patients with histologically disparate high-grade gliomas demonstrating chromosome 1p loss.

Journal of neurosurgery - 1 Jun 2000

Ino Y, Zlatescu M C, Sasaki H, Macdonald D R, Stemmer-Rachamimov A O, Jhung S, Ramsay D A, von Deimling A, Louis D N, Cairncross J G

Abstract excerpt

OBJECT: Allelic loss of chromosome 1p is a powerful predictor of tumor chemosensitivity and prolonged survival in patients with anaplastic oligodendrogliomas. Chromosome 1p loss also occurs in astrocytic and oligoastrocytic gliomas, although less commonly than in pure oligodendroglial tumors. This observation raises the possibility investigated in this study that chromosome 1p loss might also provide prognostic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Genetic Markers

Share to Glioblastoma

Share to Glioma

Share to Infant, Newborn

Share to Survival Analysis

Source

Identifiers

PMID: 10839259
DOI: 10.3171/jns.2000.92.6.0983

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long survival and therapeutic responses in patients with histologically disparate high-grade gliomas demonstrating chromosome 1p loss.PMID 10839259Read ↗

The impact of genotype on outcome in oligodendroglioma: validation of the loss of chromosome arm 1p as an important factor in clinical decision making.Semantic proximity Read ↗

Two types of chromosome 1p losses with opposite significance in gliomasSemantic proximity Read ↗

Histopathological-Molecular Genetic Correlations in Referral Pathologist-Diagnosed Low-Grade “Oligodendroglioma”Semantic proximity Read ↗

Molecular analysis of chromosome 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors.Semantic proximity Read ↗

Specific Genetic Predictors of Chemotherapeutic Response and Survival in Patients With Anaplastic OligodendrogliomasSemantic proximity Read ↗

Allelic loss of chromosome 1p and radiotherapy plus chemotherapy in patients with oligodendrogliomasSemantic proximity Read ↗

Oligodendroglial Tumors: Refinement of Candidate Regions on Chromosome Arm 1p and Correlation of 1p/19q Status with SurvivalSemantic proximity Read ↗

Correlation of histology and molecular genetic analysis of 1p, 19q, 10q, TP53, EGFR, CDK4, and CDKN2A in 91 astrocytic and oligodendroglial tumors.Semantic proximity Read ↗

Utility of in situ demonstration of 1p loss and p53 overexpression in pathologic diagnosis of oligodendroglial tumors.Semantic proximity Read ↗

Reclassification of oligoastrocytomas by loss of heterozygosity studiesSemantic proximity Read ↗

Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma.Semantic proximity Read ↗

Molecular abnormalities and correlations with tumor response and outcome in glioma patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.