Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymyxin permeabilization as a tool to investigate cytotoxicity of therapeutic aromatic alkylators in DNA repair-deficient Escherichia coli strains.

Mutation research - 8 May 2000

Salmelin C, Hovinen J, Vilpo J

Abstract excerpt

Chlorambucil (CLB; N,N-bis(2-chloroethyl)-p-aminophenylbutyric acid) and its biologically active beta-oxidation product phenylacetic acid mustard (PAM; N,N-bis(2-chloroethyl)-p-aminophenylacetic acid) are bifunctional aromatic alkylators. CLB is in wide clinical use as an anticancer drug and also as an immunosuppressant. The chemical structures indicate that CLB and PAM are mutagenic, teratogenic and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkylating Agents
Share to Cell Membrane Permeability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Culture Media

Share to DNA Repair

Share to Drug Resistance, Microbial

Share to Methylnitronitrosoguanidine

Share to Mutagenicity Tests

Share to Ultraviolet Rays

Source

Identifiers

PMID: 10838200
DOI: 10.1016/s1383-5718(00)00026-7

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Polymyxin permeabilization as a tool to investigate cytotoxicity of therapeutic aromatic alkylators in DNA repair-deficient Escherichia coli strains.PMID 10838200Read ↗

The role of base excision repair in the repair of DNA adducts formed by a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size.Semantic proximity Read ↗

Inactivation of Pathogenic Microorganisms by Photodynamic Techniques:Mechanistic Aspects and Perspective Applications.Semantic proximity Read ↗

Photodynamic action of methylene blue: repair and mutation in Escherichia coli.Semantic proximity Read ↗

Bipyridine (2,2'-dipyridyl) potentiates Escherichia coli lethality induced by nitrogen mustard mechlorethamine.Semantic proximity Read ↗

Resistance to cisplatin in an E. coli B/r NalR mutant.Semantic proximity Read ↗

Escherichia coli BTC, a human cytochrome P450 competent tester strain with a high sensitivity towards alkylating agents: involvement of alkyltransferases in the repair of DNA damage induced by aromatic amines.Semantic proximity Read ↗

Mutagenic and clastogenic characterization of poststerilized poly(3-hydroxybutyrate-co-4-hydroxybutyrate) copolymer biosynthesized by Delftia acidovorans.Semantic proximity Read ↗

Assessment of the ability of 4CMB and 4HMB to induce primary genetic damage in strains of Escherichia coli.Semantic proximity Read ↗

Among 17 inducers of differentiation only sodium butyrate causes a permanent down-regulation of c-myc in Burkitt's lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.