Article
P53 genetic polymorphism of gastric cancer in Korea.
The Korean journal of internal medicine - 1 Mar 2006
Chung Woo Chul, Lee Kang Moon, Lee Bo In, Chun Ji Sung, Lee So Yeon, Chang U-Im, Park Soo Heon, Yang Jin Mo, Choi Kyu Yong, Chung In-Sik
Abstract excerpt
BACKGROUND: Deletion or functional loss of the p53 tumor suppression gene plays a role in oncogenic transformation. The codon 72 polymorphism on exon 4 in the p53 gene produces variant proteins with either arginine (Arg) or proline (Pro), and is associated with an increased susceptibility of cancers of the lung, esophagus, breast, cervix and nasopharynx on a genetic basis. We designed this study to evaluate the...
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