Article
Association of nonsense mutation of dystrophin gene with disruption of sarcoglycan complex in X-linked dilated cardiomyopathy.
Lancet (London, England) - 20 May 2000
Franz W M, Müller M, Müller O J, Herrmann R, Rothmann T, Cremer M, Cohn R D, Voit T, Katus H A
Abstract excerpt
BACKGROUND: In a systematic analysis of inherited forms of cardiomyopathy, we previously identified a family with X-linked dilated cardiomyopathy characterised by a mutation in the rod region of dystrophin. We have now attempted to eludicate the genetic mechanism involved in this disease, as well as the role of dystrophin-associated glycoproteins. METHODS: The affected dystrophin epitope, which lacks binding to...
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