Article
Mutations in the sarcoglycan genes in patients with myopathy.
The New England journal of medicine - 27 Feb 1997
Duggan D J, Gorospe J R, Fanin M, Hoffman E P, Angelini C
Abstract excerpt
BACKGROUND: Some patients with autosomal recessive limb-girdle muscular dystrophy have mutations in the genes coding for the sarcoglycan proteins (alpha-, beta-, gamma-, and delta-sarcoglycan). To determine the frequency of sarcoglycan-gene mutations and the relation between the clinical features and genotype, we studied several hundred patients with myopathy. METHODS: Antibody against alpha-sarcoglycan was used...
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