Article
Effect of lysine infusion on urea cycle in lysinuric protein intolerance.
Metabolism: clinical and experimental - 1 May 2000
Lukkarinen M, Näntö-Salonen K, Pulkki K, Mattila K, Simell O
Abstract excerpt
Poor intestinal absorption and excessive renal loss of dibasic amino acids result in low plasma concentrations in patients with lysinuric protein intolerance (LPI). Arginine and ornithine deficiency impair the function of the urea cycle and cause hyperammonemia after protein intake, while chronic lysine deficiency may cause growth failure and lead to reduced bone density in such patients. Since high lysine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.