Article
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry - 18 May 2000
Corbett J W, Ko S S, Rodgers J D, Gearhart L A, Magnus N A, Bacheler L T, Diamond S, Jeffrey S, Klabe R M, Cordova B C, Garber S, Logue K, Trainor G L, Anderson P S, Erickson-Viitanen S K
Abstract excerpt
A series of 4-alkenyl and 4-alkynyl-3, 4-dihydro-4-(trifluoromethyl)-2-(1H)-quinazolinones were found to be potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) of human immunodeficiency virus type-1 (HIV-1). The 4-alkenyl-3, 4-dihydro-4-(trifluoromethyl)-2-(1H)-quinazolinones DPC 082 and DPC 083 and the 4-alkynyl-3, 4-dihydro-4-(trifluoromethyl)-2-(1H)-quinazolinones DPC 961 and DPC 963 were found to...
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