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Article

Difluoromethylbenzoxazole pyrimidine thioether derivatives: a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Journal of medicinal chemistry - 8 Dec 2011

Boyer Jérémie, Arnoult Eric, Médebielle Maurice, Guillemont Jérôme, Unge Johan, Jochmans Dirk

Abstract excerpt

This paper reports the synthesis and antiviral properties of new difluoromethylbenzoxazole (DFMB) pyrimidine thioether derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors. By use of a combination of structural biology study and traditional medicinal chemistry, several members of this novel class were synthesized using a single electron transfer chain process (radical nucleophilic substitution,...

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Identifiers

PMID: 22017513
DOI: 10.1021/jm200766b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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