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Identification of an Immunodominant ABC Transporter in Methicillin-Resistant Staphylococcus aureus Infections

1 Jun 2000

Abstract excerpt

Immunoblotting sera from 26 patients with septicemia due to an epidemic strain of methicillin-resistant Staphylococcus aureus (EMRSA-15), 6 of whom died, revealed an immunodominant EMRSA-15 antigen at 61 kDa. There was a statistically significant correlate (P < 0.001) between survival and immunoglobulin G to the 61-kDa band. The antigen was identified by sequencing positive clones obtained by screening a genomic...

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PMID: 10816464
DOI: 10.1128/iai.68.6.3200-3209.2000

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