Article
Dystrophin and utrophin influence fiber type composition and post-synaptic membrane structure.
Human molecular genetics - 22 May 2000
Rafael J A, Townsend E R, Squire S E, Potter A C, Chamberlain J S, Davies K E
Abstract excerpt
The X-linked muscle wasting disease Duchenne muscular dystrophy is caused by the lack of dystrophin in muscle. Protein structure predictions, patient mutations, in vitro binding studies and transgenic and knockout mice suggest that dystrophin plays a mechanical role in skeletal muscle, linking the subsarcolemmal cytoskeleton with the extracellular matrix through its direct interaction with the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.