Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men : the Suita Study.

doi:10.1161/01.cir.101.17.2060

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Article

Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men : the Suita Study.

Circulation - 2 May 2000

Higaki J, Baba S, Katsuya T, Sato N, Ishikawa K, Mannami T, Ogata J, Ogihara T

Abstract excerpt

BACKGROUND: The Framingham Study recently revealed that the homozygous deletion polymorphism of the angiotensin-converting enzyme gene (ACE DD) is associated with increased risk for essential hypertension in a male-specific manner. However, this association has not been confirmed in races other than whites. METHODS AND RESULTS: Using a large number of Japanese subjects (n=5014) that were randomly selected from...

Topics

Age Factors
Aged
Female
Genotype
Humans
Hypertension
Japan
Male
Middle Aged
Peptidyl-Dipeptidase A
Polymorphism, Genetic
Random Allocation
Sex Factors

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Open in PubMed

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PMID: 10790347
DOI: 10.1161/01.cir.101.17.2060

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