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Article

Analysis of chromosomal abnormalities in human spermatozoa using multi-colour fluorescence in-situ hybridization

1 May 2000

Abstract excerpt

There is concern that intracytoplasmic sperm injection (ICSI) may lead to offspring with a high frequency of chromosomal abnormalities. Accordingly, we studied spermatozoa sampled from eight infertile men with oligoasthenoteratozoospermia (OAT) by multi-colour fluorescence in-situ hybridization (FISH), using DNA probes for chromosomes 13, 18, 21, X and Y. Results were compared with those of spermatozoa sampled...

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PMID: 10783361
DOI: 10.1093/humrep/15.5.1107

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