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Increased incidence of numerical chromosome abnormalities in spermatozoa injected into human oocytes by ICSI

1 Jan 2001

Abstract excerpt

The potential risk of transmitting chromosomally abnormal spermatozoa from infertile males into oocytes through intracytoplasmic sperm injection (ICSI) has prompted us to investigate the male pronuclei of tripronuclear zygotes (3PN) obtained after ICSI. To specify the type of anomalies, we used triple colour fluorescent in-situ hybridization (FISH) with three specific probes for chromosomes X, Y and 18. From a...

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PMID: 11139548
DOI: 10.1093/humrep/16.1.115

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