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Article

High‐affinity LPS binding domain(s) in recombinant factor C of a horseshoe crab neutralizes LPS‐induced lethality

1 May 2000

Abstract excerpt

SSCrFCES is a biologically active, recombinant fragment of factor C, which is the endotoxin-sensitive serine protease of the LAL coagulation cascade. The approximately 38 kDa protein represents the LPS binding domain of factor C. A novel secretory signal directs the secretion of SSCrFCES into the culture supernatant of Drosophila cells, and hence it is readily purified. By differential ultrafiltration followed by...

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PMID: 10783139
DOI: 10.1096/fasebj.14.7.859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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