Changes in the outer capsid proteins of bluetongue virus serotype ten that abrogate neutralization by monoclonal antibodies.

doi:10.1016/s0168-1702(00)00130-1

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Article

Changes in the outer capsid proteins of bluetongue virus serotype ten that abrogate neutralization by monoclonal antibodies.

Virus research - 1 Mar 2000

DeMaula C D, Bonneau K R, MacLachlan N J

Abstract excerpt

Six neutralizing monoclonal antibodies (Mabs) and nine neutralization resistant viral variants (escape-mutant viruses (EMVs)) were used to further characterize the neutralization determinants of bluetongue virus serotype 10 (BTV10). The EMVs were produced by sequential passage of a highly cell culture adapted United States prototype strain of BTV10 in the presence of individual neutralizing Mabs. Mabs were...

Topics

Amino Acid Substitution
Animals
Antibodies, Monoclonal
Bluetongue virus
Capsid
Capsid Proteins
Cells, Cultured
Cricetinae
Mutation
Neutralization Tests
RNA, Viral
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA
Serotyping

Source

Open in PubMed

Identifiers

PMID: 10773319
DOI: 10.1016/s0168-1702(00)00130-1

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