Article
Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection.
AIDS research and human retroviruses - 20 Mar 2000
Markert M L, Hicks C B, Bartlett J A, Harmon J L, Hale L P, Greenberg M L, Ferrari G, Ottinger J, Boeck A, Kloster A L, McLaughlin T M, Bleich K B, Ungerleider R M, Lyerly H K, Wilkinson W E, Rousseau F S, Heath-Chiozzi M E, Leonard J M, Haase A T, Shaw G M, Bucy R P, Douek D C, Koup R A, Haynes B F, Bolognesi D P, Weinhold K J
Abstract excerpt
The purpose of this study was to determine whether thymic transplantation in addition to highly active antiretroviral therapy (HAART) will restore T cell function in HIV infection. Eight treatment-naive HIV-infected patients with CD4+ T cell counts of 200-500/mm3 were randomized into thymic transplantation and control arms. All patients received HAART (zidovudine, lamivudine, and ritonavir) for 6 weeks prior to...
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