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Article

Large and diverse numbers of human diseases with HIKE mutations.

Human molecular genetics - 12 Apr 2000

Ciccarelli F D, Acciarito A, Alberti S

Abstract excerpt

HIKE is a highly conserved sequence motif identified as a candidate pleckstrin-homology (PH) domain binding site in Gbeta proteins, protein kinases, ankyrin and kinesin. HIKE motifs occur also in gelsolin, neurogranin, neuromodulin and in the PH domain of Bruton tyrosin kinase (BTK). Phosphatidylinositol-binding sequences more distantly related to HIKE are present in gelsolin, in the G protein-coupled receptor...

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Source

Identifiers

PMID: 10767324
DOI: 10.1093/hmg/9.6.1001

Genes

BTK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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