Maturation and secretion of the non‐typable <i>Haemophilus influenzae</i> HMW1 adhesin: roles of the N‐terminal and C‐terminal domains

Abstract excerpt

Non-typable Haemophilus influenzae is a common cause of human disease and initiates infection by colonizing the upper respiratory tract. The non-typable H. influenzae HMW1 and HMW2 adhesins mediate attachment to human epithelial cells, an essential step in the process of colonization. HMW1 and HMW2 have an unusual N-terminus and undergo cleavage of a 441-amino-acid N-terminal fragment during the course of their...

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