Testicular and sperm DNA damage after treatment with fludarabine for chronic lymphocytic leukaemia

Abstract excerpt

This study investigated whether chemotherapy using fludarabine (FLU) caused testicular damage and if cytotoxicity could be detected as sperm DNA damage in the single cell Comet assay. A patient with chronic lymphocytic leukaemia requesting preservation of fertility was treated with seven monthly cycles of fludarabine (45.8 mg total dose per cycle). Testicular assessments, serum follicle stimulating hormone (FSH),...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Reproductive Biology and Fertility
• Share to Reproductive Health and Technologies
• Share to Sperm and Testicular Function