An unaffected individual from a breast/ovarian cancer family with germline mutations in both BRCA1 and BRCA2.

doi:10.1034/j.1399-0004.2000.570111.x

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Article

An unaffected individual from a breast/ovarian cancer family with germline mutations in both BRCA1 and BRCA2.

Clinical genetics - 1 Jan 2000

Moslehi R, Russo D, Phelan C, Jack E, Antman K, Narod S

Abstract excerpt

Currently many centers offer testing for three specific mutations, 185delAG, 5382insC, and 6174delT, in the BRCA1 and BRCA2 genes to Ashkenazi Jewish individuals at high risk for breast and ovarian cancer. We recently tested members of a family with multiple cases of breast and ovarian cancer (Family R014). The proband in this family tested positive for the 185delAG mutation. The unaffected sister of the proband...

Topics

Adult
BRCA2 Protein
Breast Neoplasms
Fathers
Female
Genes, BRCA1
Heterozygote
Humans
Mothers
Mutation
Neoplasm Proteins
Ovarian Neoplasms
Pedigree
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 10733239
DOI: 10.1034/j.1399-0004.2000.570111.x

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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