Article
Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation.
European journal of biochemistry - 1 Apr 2000
Sudoh S, Hua G, Kawamura Y, Maruyama K, Komano H, Yanagisawa K
Abstract excerpt
Previously, we reported that mutations in presenilin 1 (PS1) increased the intracellular levels of amyloid beta-protein (Abeta)42. However, it is still not known at which cellular site or how PS1 mutations exert their effect of enhancing Abeta42-gamma-secretase cleavage. In this study, to clarify the molecular mechanisms underlying this enhancement of Abeta42-gamma-secretase cleavage, we focused on determining...
Topics
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Animals
- Aspartic Acid Endopeptidases
- Base Sequence
- Brefeldin A
- DNA Primers
- Endopeptidases
- Endoplasmic Reticulum
- Golgi Apparatus
- Hydrolysis
- Membrane Proteins
- Mice
- Monensin