Article
In vitro characterization of five humanized OKT3 effector function variant antibodies.
Cellular immunology - 25 Feb 2000
Xu D, Alegre M L, Varga S S, Rothermel A L, Collins A M, Pulito V L, Hanna L S, Dolan K P, Parren P W, Bluestone J A, Jolliffe L K, Zivin R A
Abstract excerpt
Orthoclone OKT 3 (mOKT3) is a highly effective agent for the reversal of steroid-resistant renal allograft rejection. However, its wider use has been limited by the development of a human anti-mouse antibody response (HAMA) and by the "cytokine release syndrome" (CRS). CRS has been associated wit...
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