Modulation of phenotype and induction of irregular vessels accompany high tumorigenic potential of clonal human glioma cells xenografted to nude-rat brain.

doi:10.1002/(sici)1097-0215(20000315)85:6<819::aid-ijc15>3.0.co;2-q

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Article

Modulation of phenotype and induction of irregular vessels accompany high tumorigenic potential of clonal human glioma cells xenografted to nude-rat brain.

International journal of cancer - 15 Mar 2000

Enblad P, Hesselager G, Bongcam-Rudloff E, Hallin I, Westermark B, Nistér M

Abstract excerpt

Three phenotypically different clonal human glioma cell lines were injected stereotactically into nude-rat brains, to determine their individual growth potential and to establish an in vivo system in which different therapeutic modalities could be tested. As assessed by serial sectioning, microscopic evaluation, and computer analysis, the mean approximate tumour volume after 3-7 weeks in vivo was 0.42 mm(3) for...

Topics

Animals
Brain
Brain Neoplasms
Clone Cells
Disease Models, Animal
Glial Fibrillary Acidic Protein
Glioma
Humans
Immunohistochemistry
Intermediate Filament Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Neoplasm Transplantation

Phenotype

Rats

Rats, Nude

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 10709103
DOI: 10.1002/(sici)1097-0215(20000315)85:6<819::aid-ijc15>3.0.co;2-q

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