Mutations Abrogating the RNase Activity in Glycoprotein Ernsof the Pestivirus Classical Swine Fever Virus Lead to Virus Attenuation

Abstract excerpt

Classical swine fever (CSF) is a severe hemorrhagic disease of swine caused by the pestivirus CSF virus (CSFV). Amino acid exchanges or deletions introduced by site-directed mutagenesis into the putative active site of the RNase residing in the glycoprotein E(rns) of CSFV abolished the enzymatic activity of this protein, as demonstrated with an RNase test suitable for detection of the enzymatic activity in crude...

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