Article
The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2000
Jurutka P W, Remus L S, Whitfield G K, Thompson P D, Hsieh J C, Zitzer H, Tavakkoli P, Galligan M A, Dang H T, Haussler C A, Haussler M R
Abstract excerpt
The human vitamin D receptor (hVDR) is a ligand-regulated transcription factor that mediates the actions of the 1,25-dihydroxyvitamin D3 hormone to effect bone mineral homeostasis. Employing mutational analysis, we characterized Arg-18/Arg-22, hVDR residues immediately N-terminal of the first DNA binding zinc finger, as vital for contact with human basal transcription factor IIB (TFIIB). Alteration of either of...
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