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Article

Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1.

Glycobiology - 1 Mar 2000

Takahashi T, Honda R, Nishikawa Y

Abstract excerpt

The assembly of the lipid-linked oligosaccharide, Glc(3)Man(9)GlcNAc(2)-P-P-Dol, occurs on the rough ER membrane in an ordered stepwise manner. The process is highly conserved among eukaryotes. In order to isolate the human mannosyltransferase I (MT-I) gene involved in the process, we used the Saccharomyces cerevisiae MT-I gene ( ALG1 ), which has already been cloned. On searching the EST database with the amino...

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Topics

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Share to Amino Acid Sequence
Share to Cloning, Molecular
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Complementation Test

Share to Mannosyltransferases

Share to Saccharomyces cerevisiae

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 10704531
DOI: 10.1093/glycob/10.3.321

Genes

ALG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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