Article
DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines.
Oncogene - 17 Feb 2000
Pao M M, Liang G, Tsai Y C, Xiong Z, Laird P W, Jones P A
Abstract excerpt
A potential link between DNA repair and de novo methylation of exogenous sequences in colorectal cancer cell lines suggested that cells deficient in mismatch repair (MMR-) had an increased ability to silence the introduced virus promoter by DNA methylation due to the presence of a methylator phenotype (MET+) (Lengauer et al., 1997a). We explored this relationship in more detail and found that although there was a...
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