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Article

HPV oncoprotein E6 is a structure-dependent DNA-binding protein that recognizes four-way junctions.

Journal of molecular biology - 10 Mar 2000

Ristriani T, Masson M, Nominé Y, Laurent C, Lefevre J F, Weiss E, Travé G

Abstract excerpt

E6 is an oncoprotein implicated in cervical cancers, produced by "high-risk" human papillomaviruses. E6 is thought to promote tumorigenesis by stimulating cellular degradation of the tumour suppressor p53, but it might display other activities. Sequence similarity was recently detected between E6 and endonuclease VII, a protein of phage T4 that recognizes and cleaves four-way DNA junctions. Here, we purified...

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Identifiers

PMID: 10698626
DOI: 10.1006/jmbi.2000.3527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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