Article
Prevalence of HFE (hemochromatosis gene) mutations in unselected male patients with type 2 diabetes.
The Journal of laboratory and clinical medicine - 1 Feb 2000
Sampson M J, Williams T, Heyburn P J, Greenwood R H, Temple R C, Wimperis J Z, Jennings B A, Willis G A
Abstract excerpt
To assess the prevalence of mutations in the HFE (hemochromatosis) gene in unselected male patients with type 2 diabetes, we examined 220 white men without known diabetes and 220 age-matched white men with type 2 diabetes for mutations in the HFE gene. Nucleotide 845 (C282Y) and 187(H63D) alleles were amplified by polymerase chain reaction (PCR) with lymphocyte DNA. The PCR products were analyzed by restriction...
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