Article
One NY-ESO-1-derived epitope that promiscuously binds to multiple HLA-DR and HLA-DP4 molecules and stimulates autologous CD4+ T cells from patients with NY-ESO-1-expressing melanoma.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2005
Mandic Maja, Castelli Florence, Janjic Bratislav, Almunia Christine, Andrade Pedro, Gillet Daniel, Brusic Vladimir, Kirkwood John M, Maillere Bernard, Zarour Hassane M
Abstract excerpt
NY-ESO-1 is expressed by a broad range of human tumors and is often recognized by Abs in the sera of cancer patients with NY-ESO-1-expressing tumors. The NY-ESO-1 gene also encodes several MHC class I- and class II-restricted tumor epitopes recognized by T lymphocytes. In this study we report one novel pan-MHC class II-restricted peptide sequence, NY-ESO-1 87-111, that is capable of binding to multiple HLA-DR and...
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