Article
A common variant of the angiotensinogen gene and the risk of coronary artery disease in a German population.
Die Pharmazie - 1 Jan 2000
Reinhardt D, Sigusch H H, Vogt S F, Zeiss C, Farker K, Hoffmann A, Müller S
Abstract excerpt
The thymidine to cytosine transition at position 704 in exon 2 of the angiotensinogen gene leads to the amino acid substitution of threonine for methionine (T235 variant) and is responsible for elevated plasma levels of angiotensinogen. To examine the influence of T235 on the risk of coronary artery disease (CAD) we genotyped 184 CAD patients, 77 controls in whom CAD was excluded angiographically, and 155 healthy...
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