Article
Lack of association between variants of the angiotensinogen gene and the risk of coronary artery disease in middle-aged Japanese men.
American heart journal - 1 Aug 1997
Ichihara S, Yokota M, Fujimura T, Kato S, Hirayama H, Tsunekawa A, Inagaki H, Takatsu F, Nakashima N, Yamada Y
Abstract excerpt
The renin-angiotensin system is important in cardiovascular remodeling. Although a variant of the angiotensinogen gene is associated with an increased generation of angiotensinogen, it is unclear how this genetic variant might influence the activity of the renin-angiotensin system and thereby contribute to the predisposition to coronary artery disease (CAD). The relation between genetic polymorphisms in the...
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