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Article

Repressed Expression of the Human Xanthine Oxidoreductase Gene

1 Feb 2000

Abstract excerpt

Studies were initiated to address the basis for the low xanthine oxidoreductase (XOR) activity in humans relative to nonprimate mammalian species. The expression of the XOR in humans is strikingly lower than in mice, and both transcription rates and core promoter activity of the gene are repressed. Analysis of human XOR promoter activity in hepatocytes and vascular endothelial cells showed that the region from...

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PMID: 10681584
DOI: 10.1074/jbc.275.8.5918

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