Application of surface plasmon resonance for analysis of protein-protein interactions in the G protein-mediated signal transduction pathway.

Abstract excerpt

Hundreds of extracellular stimuli are received by cells via the pathways consisting of three basic components: cell-surface receptors, heterotrimeric G proteins, and intracellular effector enzymes or ion channels. A number of additional molecules, including G protein-coupled receptor kinases (GRKs), phosducin and Ca(2+)-binding proteins modulate signal transduction through these cascades. Understanding how these...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to GTP-Binding Proteins
• Share to Kinetics
• Share to Molecular Biology