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Article

Motor disorder in Huntington's disease begins as a dysfunction in error feedback control.

Nature - 3 Feb 2000

Smith M A, Brandt J, Shadmehr R

Abstract excerpt

A steady progression of motor dysfunction takes place in Huntington's disease (HD). The origin of this disturbance with relation to the motor control process is not understood. Here we studied reaching movements in asymptomatic HD gene-carriers (AGCs) and subjects with manifest HD. We found that movement jerkiness, which characterizes the smoothness and efficiency of motion, was a sensitive indicator of...

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Identifiers

PMID: 10676962
DOI: 10.1038/35000576
PMCID: PMC2556233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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