Article
Clinical and biologic features of adenomatosis coli in Northern Italy.
Scandinavian journal of gastroenterology - 1 Aug 1995
De Pietri S, Sassatelli R, Roncucci L, Bertoni G, Landi P, Sabadini G, Tansini P, Cavallini G, Cantoni E, Mareni C
Abstract excerpt
BACKGROUND: Familial adenomatous polyposis (FAP) is a hereditary disease characterized by more than 100 adenomas scattered in the large bowel and by various extracolonic manifestations. We proposed a) to establish the frequency of the disorder in Northern Italy, b) to describe the most relevant clinical findings, and c) in a subgroup of 21 patients (from 8 families), to evaluate the spectrum of mutations of the...
Topics
- Adenomatous Polyposis Coli
- Adult
- DNA Mutational Analysis
- Female
- Gene Frequency
- Genes, APC
- Genotype
- Humans
- Incidence
- Italy
- Male
- Middle Aged