Decreased HLA-A expression in prostate cancer is associated with normal allele dosage in the majority of cases.

doi:10.1002/(SICI)1096-9896(200002)190:2<169::AID-PATH517>3.0.CO;2-#

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Decreased HLA-A expression in prostate cancer is associated with normal allele dosage in the majority of cases.

The Journal of pathology - 1 Feb 2000

Lu Q L, Abel P, Mitchell S, Foster C, Lalani E N

Abstract excerpt

A comparison has been made of the phenotypic expression of MHC class I antigens with the corresponding HLA-A genotype in 15 cases of benign prostatic hyperplasia (BPH) and 34 cases of primary locally invasive prostatic carcinoma. Expression of class 1 protein, detected by immunocytochemistry, was partially or completely lost in approximately 90% of the tumours examined. Comparative genomic analysis of the beta2...

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Decreased HLA-A expression in prostate cancer is associated with normal allele dosage in the majority of cases.

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