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Article

[Explanation of enigmas of the Lynch syndrome thanks to a new carcinogenesis model characterized by an unorthodox initiation process].

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Dec 1999

Janin N

Abstract excerpt

The genotype-phenotype relationship of Lynch syndrome displays many enigmatic features which cannot be explained satisfactorily by the prevailing concepts of carcinogenesis and genetic predisposition to cancer. We propose here a new model of carcinogenesis divided into two and only two evolutive phases: a) a preliminary phase starting with the counter-selective loss of mismatch repair function, in which most...

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Identifiers

PMID: 10656143
DOI: 10.1016/s0764-4469(99)00101-8

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