Article
A randomized, double-blind study of the safety, transmissibility and phenotypic and genotypic stability of cold-adapted influenza virus vaccine.
The Pediatric infectious disease journal - 1 Jul 2006
Vesikari Timo, Karvonen Aino, Korhonen Tiina, Edelman Kati, Vainionpää R, Salmi Aimo, Saville Melanie K, Cho Iksung, Razmpour Ahmad, Rappaport Ruth, O'Neill Robert, Georgiu Alice, Gruber William, Mendelman Paul M, Forrest Bruce
Abstract excerpt
BACKGROUND: Live attenuated influenza vaccine (LAIV; FluMist) is a trivalent vaccine containing cold-adapted influenza vaccine viruses that infect and replicate in cells lining the nasopharynx to induce immunity. Recovery of viruses (shedding) is measured by culture of nasal specimens. Shedding of vaccine viruses is not equated with transmission because transmission requires more virus than is detected in many...
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