Article
Core histone N-termini play an essential role in mitotic chromosome condensation.
The EMBO journal - 1 Feb 2000
de la Barre A E, Gerson V, Gout S, Creaven M, Allis C D, Dimitrov S
Abstract excerpt
We have studied the role of core histone tails in the assembly of mitotic chromosomes using Xenopus egg extracts. Incubation of sperm nuclei in the extracts led to the formation of mitotic chromosomes, a process we found to be correlated with phosphorylation of the N-terminal tail of histone H3 at Ser10. When the extracts were supplemented with H1-depleted oligosomes, they were not able to assemble chromosomes....
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